Do not mix with other drugs in the same syringe or infusion fluid.Serum levels poorly correlate to body stores.1 g magnesium sulfate contains approximately 4 mmol (8 mEq) of magnesium.
Check the strength of the ampoule carefully before use. Also comes in ampoules containing 1 g (0.5 mg/ml, 2 ml) and many other dosages.If signs of overdosage are observed: stop magnesium sulfate and give 1 g calcium gluconate by slow IV route as an antidote (in this event, seizures may recur). If no signs of overdosage are observed, continue this surveillance every hour. Check patellar reflex, blood pressure, heart and respiratory rate every 15 minutes during the first hour of treatment.If delivery cannot be performed immediately in a woman with eclampsia, stop magnesium sulfate for one hour then resume magnesium sulfate perfusion until delivery. In the event of decreased urine output (< 30 ml/hour or 100 ml/4 hour), stop magnesium sulfate and perform delivery as soon as possible. For the neonate: hypotonia, neurobehavioural impairment, apnoea, respiratory depression.For the mother: diminished then absent patellar reflex (early sign), hypotension, drowsiness, confusion, difficulty in speaking, bradycardia, respiratory depression (respiratory rate in case of overdosage (hypermagnesaemia):.pain at the injection site, warm flushes decreased fetal heart rate.Reduce the dose in patients with renal impairment do not administer to patients with severe renal impairment.If seizures persist or recur, administer a further 2 g (patients less than 70 kg) to 4 g by IV infusion, without exceeding 8 g total dose during the first hour.Ĭontra-indications, adverse effects, precautions.Continue the treatment for 24 hours after the delivery or the last seizure.5 g ampoule (0,5 g/ml, 10 ml) for IM injection or IV infusionĤ g by IV infusion in 100 ml of 0.9% sodium chloride over 15 to 20 minutes then, 10 g by IM route (5 g in each buttock) then, 5 g by IM route every 4 hours (changing buttock for each injection)Ĥ g by IV infusion in 100 ml of 0.9% sodium chloride over 15 to 20 minutes then 1 g per hour by continuous IV infusion.Eclampsia: treatment of eclamptic seizures and prevention of recurrenceįorms and strengths, route of administration.Severe pre-eclampsia: prevention of eclamptic seizures.
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